The
guinea pig (
Cavia porcellus), also called the
cavy or
domestic guinea pig, is a species of
rodent belonging to the family
Caviidae and the genus
Cavia. Despite their
common name, these animals are not in the
pig family, nor are they from
Guinea. They originated in the
Andes, and earlier studies based on biochemistry and
hybridization suggested they are
domesticated descendants of a closely related species of cavy such as
Cavia aperea,
C. fulgida, or
C. tschudii and, therefore, do not exist naturally in the wild.
[1][2] Recent studies applying molecular markers,
[3][4] in addition to studying the skull and skeletal morphology of current and mummified animals,
[5] revealed that the ancestor is most likely
Cavia tschudii.
The domestic guinea pig plays an important role in the
folk culture of many
Indigenous South American groups, especially as a food source, but also in
folk medicine and in community religious ceremonies. Since the 1960s, efforts have been made to increase consumption of the animal outside South America.
[7]
In
Western societies, the domestic guinea pig has enjoyed widespread popularity as a household
pet
since its introduction by European traders in the 16th century. Their
docile nature and responsiveness to handling and feeding, and the
relative ease of caring for them, continue to make guinea pigs a popular
pet. Organizations devoted to
competitive breeding of guinea pigs have been formed worldwide, and many
specialized breeds of guinea pig, with varying coat colors and compositions, are cultivated by breeders.
Biological experimentation on guinea pigs has been carried out since the 17th century. The animals were frequently used as
model organisms in the 19th and 20th centuries, resulting in the
epithet "guinea pig" for a
test subject, but have since been largely replaced by other rodents such as
mice and
rats. They are still used in research, primarily as models for human medical conditions such as
juvenile diabetes,
tuberculosis,
scurvy, and
pregnancy complications.
History
The guinea pig was first
domesticated as early as 5000 BC for food by tribes in the
Andean region of
South America (the present-day southern part of
Colombia,
Ecuador,
Peru, and
Bolivia), some thousands of years after the domestication of the South American
camelids.
[9] Statues dating from
circa 500 BC to 500 AD that depict guinea pigs have been unearthed in archaeological digs in Peru and Ecuador. The
Moche people of ancient Peru worshipped animals and often depicted the guinea pig in their art.
[11] From about 1200 AD to the
Spanish conquest
in 1532, selective breeding resulted in many varieties of domestic
guinea pigs, which form the basis for some of the modern domestic
breeds.
[12]
They continue to be a food source in the region; many households in the
Andean highlands raise the animal, which subsists on the family's
vegetable scraps.
Folklore traditions involving guinea pigs are numerous; they are
exchanged as gifts, used in customary social and religious ceremonies,
and frequently referenced in spoken metaphors. They also play a role in traditional healing rituals by folk doctors, or
curanderos, who use the animals to diagnose diseases such as
jaundice,
rheumatism,
arthritis, and
typhus. They are rubbed against the bodies of the sick, and are seen as a supernatural medium. Black guinea pigs are considered especially useful for diagnoses. The animal also may be cut open and its entrails examined to determine whether the cure was effective. These methods are widely accepted in many parts of the Andes, where Western medicine is either unavailable or distrusted.
Spanish,
Dutch, and
English traders brought guinea pigs to
Europe, where they quickly became popular as
exotic pets among the upper classes and royalty, including
Queen Elizabeth I. The earliest known written account of the guinea pig dates from 1547, in a description of the animal from
Santo Domingo; because cavies are not native to
Hispaniola, the animal was earlier believed to have been introduced there by Spanish travelers.
[1]
However, based on more recent excavations on West Indian islands, the
animal must have been introduced by ceramic-making horticulturalists
from South America to the Caribbean around 500 BC,
[20] and it was present in the
Ostionoid period, for example, on
Puerto Rico,
[21] long before the advent of the Spaniards. The guinea pig was first described in the West in 1554 by the
Swiss naturalist
Conrad Gessner.
[22] Its
binomial scientific name was first used by
Erxleben in 1777; it is an amalgam of
Pallas'
generic designation (1766) and
Linnaeus'
specific conferral (1758).
[1] The earliest known illustration of a domestic guinea pig is a painting (artist unknown) in the collection of the
National Portrait Gallery
in London, dated to 1580, which shows a girl in typical Elizabethan
dress holding a tortoise-shell guinea pig in her hands; she is flanked
by her two brothers, one of whom holds a pet bird.
[23]
The picture dates from the same period as the oldest recorded guinea
pig remains in England, which are a partial cavy skeleton found at
Hill Hall (Essex), an Elizabethan manor house, and dated to around 1575.
[23]
Name
The scientific name of the common species is
Cavia porcellus, with
porcellus being
Latin for "little pig".
Cavia is
New Latin; it is derived from
cabiai, the animal's name in the language of the
Galibi tribes once native to
French Guiana.
[24] Cabiai may be an adaptation of the
Portuguese çavia (now
savia), which is itself derived from the
Tupi word
saujá, meaning rat.
[25] Guinea pigs are called
quwi or
jaca in
Quechua and
cuy or
cuyo (plural
cuyes, cuyos) in the
Spanish of Ecuador, Peru, and Bolivia.
[26] Ironically,
breeders
tend to use the more formal "cavy" to describe the animal, while in
scientific and laboratory contexts, it is far more commonly referred to
by the more colloquial "guinea pig".
[27]
How the animals came to be called "pigs" is not clear. They are built somewhat like
pigs,
with large heads relative to their bodies, stout necks, and rounded
rumps with no tail of any consequence; some of the sounds they emit are
very similar to those made by pigs, and they also spend a large amount
of time eating.
[27][28] They can survive for long periods in small quarters, like a 'pig pen', and were thus easily transported on ships to Europe.
[27]
The animal's name alludes to pigs in many European languages. The
German word for them is
Meerschweinchen, literally "little sea pig", which has been translated into
Polish as
świnka morska, into
Hungarian as
tengerimalac, and into
Russian as
морская свинка. This derives from the
Middle High German name
merswin. This originally meant "
dolphin" and was used because of the animals' grunting sounds (which were thought to be similar).
[29]
Many other, possibly less scientifically based explanations of the
German name exist. For example, sailing ships stopping to reprovision in
the
New World would pick up stores of guinea pigs, which provided an easily transportable source of fresh meat. The
French term is
cochon d'Inde (Indian pig) or
cobaye; the
Dutch call it
Guinees biggetje (Guinean piglet) or cavia (while in some Dutch dialects it is called
Spaanse rat); and in
Portuguese, the guinea pig is variously referred to as
cobaia, from the Tupi word via its Latinization, or as
porquinho da Índia (little Indian pig). This is not universal; for example, the common word in Spanish is
conejillo de Indias (little rabbit of the Indies).
[26] The Chinese refer to them as 豚鼠 (
túnshǔ, 'pig mouse'), and sometimes as Netherlands pig (荷蘭豬,
hélánzhū) or Indian mouse (天竺鼠,
tiānzhúshǔ). The Japanese word for guinea pig is "モルモット" (
morumotto), which derives from the name of another mountain-dwelling rodent, the
marmot; this is what guinea pigs were called by the Dutch traders who first brought them to Nagasaki in 1843.
The origin of "guinea" in "guinea pig" is harder to explain. One
proposed explanation is that the animals were brought to Europe by way
of
Guinea, leading people to think they had originated there.
[27]
"Guinea" was also frequently used in English to refer generally to any
far-off, unknown country, so the name may simply be a colorful reference
to the animal's exotic appeal.
[30][31] Another hypothesis suggests the "guinea" in the name is a corruption of "
Guiana", an area in
South America, though the animals are not native to that region.
[30][32] A common misconception is that they were so named because they were sold for the price of a
guinea coin; this hypothesis is untenable, because the guinea was first struck in England in 1663, and
William Harvey used the term "Ginny-pig" as early as 1653.
[33] Others believe "guinea" may be an alteration of the word
coney (rabbit); guinea pigs were referred to as "pig coneys" in
Edward Topsell's 1607 treatise on
quadrupeds.
[27]
Traits and environment
Two parti-colored Abyssinian guinea pigs
Guinea pigs are large for rodents, weighing between 700 and 1,200 g
(1.5 and 2.6 lb), and measuring between 20 and 25 cm (8 and 10 in) in
length.
[34] They typically live an average of four to five years, but may live as long as eight years. According to the 2006
Guinness World Records, the longest living guinea pig survived 14 years, 10.5 months.
[36]
In the 1990s, a
minority scientific opinion emerged proposing that
caviomorphs, such as guinea pigs,
chinchillas, and
degus, are not rodents and should be
reclassified as a separate
order of mammals (similar to
lagomorphs).
[37][38]
Subsequent research using wider sampling has restored consensus among
mammalian biologists that the current classification of rodents as
monophyletic is justified.
[39][40]
Natural habitat
C. porcellus is not found naturally in the wild; it is likely descended from some closely related species of
cavies, such as
C. aperea,
C. fulgida, and
C. tschudii, which are still commonly found in various regions of South America.
[1] Some species of cavy identified in the 20th century, such as
C. anolaimae and
C. guianae, may be domestic guinea pigs that have become
feral by reintroduction into the wild.
[12] Wild cavies are found on grassy plains and occupy an
ecological niche similar to that of
cattle.
They are social, living in the wild in small groups which consist of
several females (sows), a male (boar), and the young (which in a break
with the preceding
porcine nomenclature are called pups). They move together in groups (
herds) eating grass or other vegetation, and do not store food.
[41] While they do not
burrow or build nests, they frequently seek shelter in the burrows of other animals, as well as in crevices and tunnels formed by
vegetation.
[41] They
tend to be most active during dawn and dusk, when it is harder for predators to spot them.
[42]
Domestic habitat
Domesticated
guinea pigs thrive in groups of two or more; groups of sows, or groups
of one or more sows and a neutered boar are common combinations. Guinea
pigs learn to recognize and bond with other individual guinea pigs, and
testing of boars shows their
neuroendocrine
stress response is significantly lowered in the presence of a bonded
female when compared to the presence of unfamiliar females.
[43]
Groups of boars may also get along, provided their cage has enough
space, they are introduced at an early age, and no females are present.
[44]
Domestic guinea pigs have developed a different biological rhythm from
their wild counterparts, and have longer periods of activity followed by
short periods of sleep in between.
[42] Activity is scattered randomly over the day; aside from avoidance of intense light, no regular
circadian patterns are apparent.
[42]
This
cat has
accepted this pair of guinea pigs. The success of this type of
interspecies interaction varies according to the individual animals
involved.
Domestic guinea pigs generally live in cages, although some owners of
large numbers of guinea pigs dedicate entire rooms to their pets. Cages
with solid or wire mesh floors are used, although wire mesh floors can
cause injury and may be associated with an infection commonly known as
bumblefoot (ulcerative pododermatitis). "Cubes and
Coroplast" (or C&C) style cages are now a common choice.
[46] Cages are often lined with wood shavings or a similar material. Bedding made from red cedar (
Eastern or
Western) and
pine, both
softwoods, were commonly used in the past, but these materials are now believed to contain harmful
phenols (aromatic hydrocarbons) and oils.
[47] Safer beddings made from
hardwoods (such as
aspen), paper products, and corn cob materials are other alternatives.
[47]
Guinea pigs tend to be messy within their cages; they often jump into
their food bowls or kick bedding and feces into them, and their
urine sometimes crystallizes on cage surfaces, making it difficult to remove.
[48]
After its cage has been cleaned, a guinea pig typically urinates and
drags its lower body across the floor of the cage to mark its territory.
[49] Male guinea pigs may also mark their territory in this way when they are taken out of their cages.
Guinea pigs do not generally thrive when housed with other species. Housing of guinea pigs with other rodents such as
gerbils and
hamsters may increase instances of respiratory and other infections,
[50] and such rodents may act aggressively toward the guinea pig.
[51] Larger animals may regard guinea pigs as
prey, though some (such as
dogs) can be trained to accept them.
[52] Opinion is divided over the cohousing of guinea pigs and
domestic rabbits. Some published sources say that guinea pigs and rabbits complement each other well when sharing a cage.
[52][53] However, as
lagomorphs, rabbits have different nutritional requirements, so the two species cannot be fed the same food.
[54] Rabbits may also harbor diseases (such as respiratory infections from
Bordetella and
Pasteurella), to which guinea pigs are susceptible.
[55] Even the
dwarf rabbit is much stronger than the guinea pig and may cause intentional or inadvertent injury.
[56]
Behavior
Guinea pigs can learn complex paths to food, and can accurately
remember a learned path for months. Their strongest problem-solving
strategy is motion.
[57]
While guinea pigs can jump small obstacles, they are poor climbers, and
are not particularly agile. They startle extremely easily, and either
freeze in place for long periods or run for cover with rapid, darting
motions when they sense danger.
[42] Larger groups of startled guinea pigs "stampede", running in haphazard directions as a means of confusing predators.
[58]
When excited, guinea pigs may repeatedly perform little hops in the air
(known as "popcorning"), a movement analogous to the ferret's
war dance.
[59] They are also exceedingly good swimmers.
[60]
Guinea pigs "social groom"
Like many rodents, guinea pigs sometimes participate in
social grooming, and they regularly self-groom.
[61] A milky-white substance is secreted from their eyes and rubbed into the hair during the grooming process.
Groups of boars often chew each other's hair, but this is a method of
establishing hierarchy within a group, rather than a social gesture.
[60] Dominance is also established through biting (especially of the ears),
piloerection, aggressive noises, head thrusts, and leaping attacks.
[63] Non-sexual simulated
mounting for dominance is also common among same-sex groups.
Guinea pig sight is not as good as that of a human, but they have a
wider angle of vision (about 340°) and see in partial color (
dichromacy). They have well-developed senses of hearing,
smell, and touch.
[64][65] Vocalization is the primary means of communication between members of the species.
[66] These are the most common sounds made by the guinea pig:
[67]
- A "wheek" is a loud noise, the name of which is onomatopoeic,
also known as a whistle. An expression of general excitement, it may
occur in response to the presence of its owner or to feeding. It is
sometimes used to find other guinea pigs if they are running. If a
guinea pig is lost, it may wheek for assistance. listen (help·info)
- A bubbling or purring sound is made when the guinea pig is enjoying
itself, such as when being petted or held. It may also make this sound
when grooming, crawling around to investigate a new place, or when given
food. listen (help·info)
- A rumbling sound is normally related to dominance within a group,
though it can also come as a response to being scared or angry. In these
cases, the rumble often sounds higher and the body vibrates shortly.
While courting, a male usually purrs deeply, swaying and circling the
female[68] in a behavior called "rumblestrutting". A low rumble while walking away reluctantly shows passive resistance. listen (help·info)
- Chutting and whining are sounds made in pursuit situations, by the pursuer and pursuee, respectively. listen (help·info)
- A chattering sound is made by rapidly gnashing the teeth, and is generally a sign of warning. Guinea pigs tend to raise their heads when making this sound.
- Squealing or shrieking is a high-pitched sound of discontent, in response to pain or danger. listen (help·info)
- Chirping, a less-common sound, likened to bird song,
seems to be related to stress, or when a baby guinea pig wants to be
fed. Very rarely, the chirping will last for several minutes. listen (help·info)
Breeding
Pregnant sow one week before delivering three pups
The guinea pig is able to breed year-round, with birth peaks usually
coming in the spring; as many as five litters can be produced per year.
[12] The
gestation period lasts from 59–72 days, with an average of 63–68 days.
[49] Because of the long gestation period and the large size of the pups, pregnant females may become large and
eggplant-shaped, although the change in size and shape varies. Unlike the offspring of most other
rodents, which are
altricial at birth, newborn pups are well-developed with hair, teeth, claws, and partial eyesight;
[60] they are immediately mobile, and begin eating solid food immediately, though they continue to
suckle.
Litters yield one to six pups, with an average of three; the largest recorded litter size is 17.
[70]
In smaller litters, difficulties may occur during labour due to over-sized pups. Large litters result in higher incidences of
stillbirth,
but because the pups are delivered at an advanced stage of development,
lack of access to the mother's milk has little effect on the mortality
rate of newborns.
[71] Cohabitating females assist in mothering duties if lactating.
[72]
Guinea pigs also practice
alloparental care,
in which a female may adopt the pup or pups of another. This might take
place if the original parents die or are for some reason separated from
them. This behavior is common, and is seen in many other animal species
such as the elephant.
[73]
Male and female guinea pigs do not
differ in external appearance
apart from general size. The position of the anus is very close to the
genitals in both sexes. Female genitals are distinguished by a Y-shaped
configuration formed from a vulvar flap, while the male genitals may
look similar, with the penis and anus forming a like shape, the penis
will protrude if pressure is applied to the surrounding hair. The male's testes may also be visible externally from scrotal swelling.
Guinea pig pup at eight hours old
Males reach sexual maturity at 3–5 weeks; females can be fertile as
early as four weeks and can carry litters before they are adults. Females that have never given birth may develop irreversible fusing of the
pubic symphysis, a joint in the
pelvis, due to calcification which may occur between six and 10 months of age.
[49]:73 If they become pregnant after this has happened, the birth canal will not widen sufficiently; this may lead to
dystocia and death as they attempt to give birth.
Calcification of the female's pubic symphysis (if not bred) is a common
myth. The reason for potential calcification is a metabolic disease,
like
ochronosis. A healthy, normal female guinea pig's pubic symphysis does not calcify.
[78] Females can become pregnant 6–48 hours after giving birth, but it is not healthy for a female to be thus constantly pregnant.
Toxemia of pregnancy
is common and kills many pregnant females. Signs of toxemia include
anorexia, lack of energy, excessive salivation, a sweet or fruity breath
odor due to
ketones, and
seizures in advanced cases. Pregnancy toxemia appears to be most common in hot climates. Other serious complications of pregnancy can include a
prolapsed uterus,
hypocalcaemia, and
mastitis.
Diet
A silver agouti guinea pig eating grass
A short-haired guinea pig eating a piece of apple
Grass is the guinea pig's natural diet. Their
molars are particularly suited for grinding plant matter, and grow continuously throughout the animal's life.
[83] Most grass-eating mammals are quite large and have a long digestive tract; while guinea pigs have much longer
colons than most rodents, they must also supplement their diet by
coprophagy, the eating of their own feces. However, they do not consume all their feces indiscriminately, but produce special soft pellets, called
cecotropes, which recycle
B vitamins, fiber, and bacteria required for proper digestion.
[85][86] The cecotropes (or caecal pellets) are eaten directly from the anus, unless the guinea pig is pregnant or obese.
[54] They share this behaviour with
rabbits.
In geriatric boars or sows (the condition is rarer in young ones), the
muscles which allow the softer pellets to be expelled from the anus for
consumption can become weak. This creates a condition known as anal
impaction, which prevents the boar from redigesting cecotropes, though
harder pellets may pass through the impacted mass. The condition may be temporarily alleviated by carefully expelling the impacted feces.
Guinea pigs benefit from feeding on fresh grass hay, such as
timothy hay, in addition to food pellets which are often based from timothy.
Alfalfa is also a popular food choice; most guinea pigs will eat large amounts of alfalfa when offered it,
[88]
though some controversy exists over the feeding of alfalfa to adult
guinea pigs. Some pet owners and veterinary organizations have advised
that, as a
legume rather than a grass hay, alfalfa consumed in large amounts may lead to
obesity, as well as
bladder stones due to excess
calcium, in any but pregnant and very young guinea pigs.
[89][90] However, published scientific sources mention alfalfa as a source for replenishment of protein,
amino acids, and fiber.
[91][92][93]
Like humans, but unlike most other
mammals, guinea pigs cannot synthesize their own
vitamin C
and must obtain this vital nutrient from food. If guinea pigs do not
ingest enough vitamin C, they can suffer from potentially fatal
scurvy.
Guinea pigs require about 10 mg of vitamin C daily (20 mg if pregnant),
which can be obtained through fresh, raw fruits and vegetables (such as
broccoli, apple, cabbage, carrot, celery, and spinach) or through
dietary supplements. Healthy diets for guinea pigs require a complex balance of calcium,
magnesium,
phosphorus,
potassium, and
hydrogen ions; adequate amounts of vitamins
E,
A, and
D are also necessary.
[95] Imbalanced diets have been associated with
muscular dystrophy,
metastatic calcification, difficulties with pregnancy, vitamin deficiencies, and teeth problems.
[96]
Guinea pigs tend to be fickle eaters when it comes to fresh fruits and
vegetables, having learned early in life what is and is not appropriate
to consume, and their habits are difficult to change after maturity.
[92] They do not respond well to sudden changes in diet; they may stop eating and starve rather than accept new food types.
[60]
A constant supply of hay or other food is generally recommended, as
guinea pigs feed continuously and may develop habits such as chewing on
their own hair if food is not present. Because guinea pigs' teeth grow constantly, they routinely
gnaw, lest their teeth become too large for their mouths, a common problem in
rodents.
[46] Guinea pigs also chew on cloth, paper, plastic, and rubber.
A number of plants are poisonous to guinea pigs, including
bracken,
bryony,
buttercup,
charlock,
deadly nightshade,
foxglove,
hellebore,
hemlock,
lily of the valley,
mayweed,
monkshood,
privet,
ragwort,
rhubarb,
speedwell, toadflax (both
Linaria vulgaris and
Linaria dalmatica), and
wild celery. Additionally, any plant which grows from a
bulb (e.g.,
tulip or
onion) is normally considered poisonous, as well as ivy and oak tree leaves.
Health
A parti-colored guinea pig suffering from
torticollis, or wry neck
Common ailments in domestic guinea pigs include
respiratory tract infections,
diarrhea, scurvy (vitamin C deficiency, typically characterized by sluggishness),
abscesses due to infection (often in the neck, due to hay embedded in the throat, or from external scratches), and infections by
lice,
mites, or
fungus.
Mange mites (
Trixacarus caviae) are a common cause of hair
loss, and other symptoms may also include excessive scratching,
unusually aggressive behavior when touched (due to pain), and, in some
instances, seizures. Guinea pigs may also suffer from "running lice" (
Gliricola porcelli),
a small, white insect which can be seen moving through the hair; their
eggs, which appear as black or white specks attached to the hair, are
sometimes referred to as "static lice". Other causes of hair loss can be
due to hormonal upsets caused by underlying medical conditions such as
ovarian cysts.
Foreign bodies, especially small pieces of hay or straw, can become
lodged in the eyes of guinea pigs, resulting in excessive blinking,
tearing, and in some cases an opaque film over the eye due to
corneal ulcer. Hay or straw dust can also cause
sneezing. While it is normal for guinea pigs to sneeze periodically, frequent sneezing may be a symptom of
pneumonia, especially in response to atmospheric changes. Pneumonia may also be accompanied by
torticollis and can be fatal.
Because the guinea pig has a stout, compact body, it more easily tolerates excessive cold than excessive heat.
[107] Its normal
body temperature is 101–104 °F (38–40 °C),
[108] so its ideal ambient air temperature range is similar to a human's, about 65–75 °F (18–24 °C).
[107] Consistent ambient temperatures in excess of 90 °F (32 °C) have been linked to
hyperthermia and death, especially among pregnant sows.
[107] Guinea pigs are not well suited to environments that feature wind or frequent drafts,
[109] and respond poorly to extremes of
humidity outside of the range of 30–70%.
[110]
Guinea pigs are
prey
animals whose survival instinct is to mask pain and signs of illness,
and many times health problems may not be apparent until a condition is
severe or in its advanced stages. Treatment of disease is made more
difficult by the extreme sensitivity guinea pigs have to most
antibiotics, including
penicillin, which kill off the
intestinal flora and quickly bring on episodes of diarrhea and in some cases, death.
[111]
Similar to the inherited
genetic diseases of other breeds of animal (such as
hip dysplasia in canines), a number of genetic abnormalities of guinea pigs have been reported. Most commonly, the
roan coloration of
Abyssinian guinea pigs is associated with
congenital eye disorders and problems with the digestive system. Other genetic disorders include "waltzing disease" (deafness coupled with a tendency to run in circles),
palsy, and
tremor conditions.
[114]
Pets
Handling, temperament and socialization
If handled correctly early in life, guinea pigs become amenable to being picked up and carried, and seldom bite or scratch.
[60] They are timid explorers and often hesitate to attempt an escape from their cage even when an opportunity presents itself.
[53]
Still, they show considerable curiosity when allowed to walk freely,
especially in familiar and safe terrain. Guinea pigs that become
familiar with their owner will whistle on the owner's approach; they
will also learn to whistle in response to the rustling of plastic bags
or the opening of refrigerator doors, where their food is most commonly
stored. In Switzerland, owning a single guinea pig is considered harmful
to its well-being and forbidden by law.
[115]
Appearance, coat and grooming
Black-haired Silkie Guinea pig
Domesticated
guinea pigs occur in many breeds, which have been developed since their
introduction to Europe and North America. These varieties vary in hair
and color composition. The most common varieties found in pet stores are
the English shorthair (also known as the American), which have a short,
smooth coat, and the
Abyssinian, whose coat is ruffled with
cowlicks, or
rosettes. Also popular among breeders are the
Peruvian and the
Sheltie (or Silkie), both straight longhair breeds, and the
Texel,
a curly longhair. Grooming of guinea pigs is primarily accomplished
using combs or brushes. Shorthair breeds are typically brushed weekly,
while longhair breeds may require daily grooming.
[116]
Clubs and associations
Cavy clubs and associations dedicated to the showing and breeding of
guinea pigs have been established worldwide. The American Cavy Breeders
Association, an adjunct to the
American Rabbit Breeders' Association, is the governing body in the United States and Canada.
[117] The
British Cavy Council governs cavy clubs in the United Kingdom. Similar organizations exist in Australia (Australian National Cavy Council)
[118] and New Zealand (New Zealand Cavy Council).
[119] Each club publishes its own standard of perfection and determines which breeds are eligible for showing.
Allergies to pet guinea pigs
Allergic symptoms, including
rhinitis,
conjunctivitis, and
asthma, have been documented in laboratory animal workers who come into contact with guinea pigs.
[120][121] Allergic reactions following direct exposure to guinea pigs in domestic settings have also been reported.
[120]
Two major guinea pig allergens, Cav p I and Cav p II, have been
identified in guinea pig fluids (urine and saliva) and guinea pig
dander.
[120] People who are allergic to guinea pigs are usually allergic to hamsters and gerbils, as well.
[122] Allergy shots can successfully treat an allergy to guinea pigs, although treatment can take up to 18 months.
Cultural and media influence
A lilac, orange, and white Satin Peruvian guinea pig (show-length coat)
As a result of their widespread popularity, especially in households
with children, guinea pigs have shown a presence in culture and media.
Some noted appearances of the animal in
literature include the short story "
Pigs Is Pigs" by
Ellis Parker Butler, which is a tale of
bureaucratic
incompetence. Two guinea pigs held at a railway station breed unchecked
while humans argue as to whether they are "pigs" or "pets" for the
purpose of determining freight charges.
[123] Butler's story, in turn, inspired the
Star Trek: The Original Series episode "
The Trouble With Tribbles", written by
David Gerrold.
[124] In the
Golden Hamster Saga books, two guinea pigs named Enrico and Caruso are modern-day thespians (named after
Enrico Caruso) who serve as secondary characters, and often irritate the main character,
Freddy Auratus, that strongly dislikes their acting antics.
In children's literature
The Fairy Caravan, a novel by
Beatrix Potter,
[125] and
Michael Bond's
Olga da Polga series for children,
[126] both feature guinea pigs as the
protagonist. Another appearance is in
The Magician's Nephew by
C. S. Lewis: in the first (chronologically) of his
The Chronicles of Narnia series, a guinea pig is the first creature to travel to the
Wood between the Worlds.
[127] In
Ursula Dubosarsky's
Maisie and the Pinny Gig,
a little girl has a recurrent dream about a giant guinea pig, while
guinea pigs feature significantly in several of Dubosarsky's other
books, including the young adult novel
The White Guinea Pig and
The Game of the Goose.
[128]
In film and television
Guinea pigs have also been featured in film and television. In the TV movie
Shredderman Rules,
the main character and the main character's crush both have guinea pigs
which play a minor part in the plot. A guinea pig named Rodney, voiced
by
Chris Rock, was a prominent character in the 1998 film
Dr. Dolittle, and Linny the Guinea pig is a co-star on
Nick Jr.'s
Wonder Pets. Guinea pigs were used in some major
advertising campaigns in the 1990s and 2000s, notably for
Egg Banking plc,
[129] Snapple, and
Blockbuster Video.
[130]
The Blockbuster campaign is considered by some guinea pig advocates to
have been a factor in the rise of caging guinea pigs and rabbits
together.
[56] In the
South Park season 12 episode "
Pandemic 2: The Startling", giant guinea pigs dressed in costumes rampage over the Earth.
[131] The 2009
Walt Disney Pictures movie
G-Force
features a group of highly intelligent guinea pigs trained as
operatives of the U.S. government. A video game based on the movie was
also released. A guinea pig named Bugsy appears in the 2008 film
Bedtime Stories. A guinea pig named Cashew features prominently in the second season of the U.S. adaptation of
House of Cards.
Scientific research
The use of guinea pigs in scientific experimentation dates back at least to the 17th century, when the Italian biologists
Marcello Malpighi and
Carlo Fracassati conducted
vivisections of guinea pigs in their examinations of
anatomic structures.
[132] In 1780,
Antoine Lavoisier used a guinea pig in his experiments with the
calorimeter,
a device used to measure heat production. The heat from the guinea
pig's respiration melted snow surrounding the calorimeter, showing that
respiratory gas exchange is a
combustion, similar to a candle burning.
[133] Guinea pigs played a major role in the establishment of
germ theory in the late 19th century, through the experiments of
Louis Pasteur,
Émile Roux, and
Robert Koch.
[134] Guinea pigs have been
launched into orbital space flight several times, first by the
USSR on the
Sputnik 9 biosatellite of March 9, 1961 – with a successful recovery.
[135] China also launched and recovered a biosatellite in 1990 which included guinea pigs as passengers.
[136]
In
English,
the term 'guinea pig' is commonly used as a metaphor for a subject of
scientific experimentation, or any experiment or test in modern times.
This dates back to the early 20th century; the
Oxford English Dictionary notes its first usage in this capacity in 1913.
[137] In 1933,
Consumers Research founders
F. J. Schlink and
Arthur Kallet wrote a book entitled
100,000,000 Guinea Pigs, extending the metaphor to consumer society.
[138] The book became a national bestseller in the United States, thus further popularizing the term, and spurred the growth of the
consumer protection movement.
[139] The negative connotation of the term was later employed in the novel
The Guinea Pigs by
Czech author
Ludvík Vaculík as an allegory for
Soviet totalitarianism.
[140]
Guinea pigs were popular laboratory animals until the later 20th
century; about 2.5 million guinea pigs were used annually in the U.S.
for research in the 1960s,
[141] but that total decreased to about 375,000 by the mid-1990s.
[60] As of 2007, they constitute about 2% of the current total of laboratory animals.
[141] In the past, they were widely used to standardize
vaccines and
antiviral agents; they were also often employed in studies on the production of
antibodies in response to extreme
allergic reactions, or
anaphylaxis.
[142] Less common uses included research in
pharmacology and
irradiation.
[142]
Since the middle 20th century, they have been replaced in laboratory
contexts primarily by mice and rats. This is in part because research
into the genetics of guinea pigs has lagged behind that of other
rodents, although geneticists
W. E. Castle and
Sewall Wright made a number of contributions to this area of study, especially regarding
coat color.
[114][143] In 2004, the U.S.'s
National Human Genome Research Institute announced plans to sequence the
genome of the domestic guinea pig.
[144]
The guinea pig was most extensively implemented in research and diagnosis of
infectious diseases.
[142] Common uses included identification of
brucellosis,
Chagas disease,
cholera,
diphtheria,
foot-and-mouth disease,
glanders,
Q fever,
Rocky Mountain spotted fever, and various strains of
typhus.
[142] They are still frequently used to diagnose
tuberculosis, since they are easily infected by human tuberculosis bacteria.
[141] Because guinea pigs are one of the few animals which, like humans and other
primates, cannot synthesize vitamin C, but must obtain it from their diet, they are ideal for researching scurvy.
[141]
From the accidental discovery in 1907 that scurvy could be induced in
guinea pigs, to their use to prove the chemical structure of the
"ascorbutic factor" in 1932, the guinea pig model proved a crucial part
of vitamin C research.
[145][146]
Complement, an important component for
serology, was first isolated from the blood of the guinea pig.
[141] Guinea pigs have an unusual insulin mutation,
[147] and are a suitable species for the generation of anti-insulin antibodies.
[148]
Present at a level 10 times that found in other mammals, the insulin in
guinea pigs may be important in growth regulation, a role usually
played by
growth hormone.
[149] Additionally, guinea pigs have been identified as
model organisms for the study of juvenile diabetes and, because of the frequency of pregnancy toxemia, of pre-eclampsia in human females.
[72]
Their placental structure is similar to that of humans, and their
gestation period can be divided into trimesters that resemble the stages
of fetal development in humans.
[150]
Guinea pig
strains
used in scientific research are primarily outbred strains. Aside from
the common American or English stock, the two main outbred strains in
laboratory use are the Hartley and Dunkin-Hartley; these English strains
are
albino, although pigmented strains are also available.
[151] Inbred strains
are less common and are usually used for very specific research, such
as immune system molecular biology. Of the inbred strains that have been
created, the two still used with any frequency are, following Sewall
Wright's designations, "Strain 2" and "Strain 13".
[114][151]
Hairless breeds of guinea pigs have been used in scientific research since the 1980s, particularly for
dermatological studies. A hairless and
immunodeficient breed was the result of a spontaneous genetic mutation in inbred laboratory strains from the Hartley stock at the
Eastman Kodak Company in 1979.
[152] An immunocompetent hairless breed was also identified by the
Institute Armand Frappier in 1978, and
Charles River Laboratories has reproduced this breed for research since 1982.
[153] Cavy fanciers then began acquiring hairless breeds, and the pet hairless varieties are referred to as "
skinny pigs".